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LY 2940680

LY 2940680

LY2940680 is a potent agent used to treat cancer. A study will explore the changes in a cancer marker level in skin, hair follicles and tumor cells. F...
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VU 0357121

VU 0357121

VU-0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax. Its site of action...
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Salmeterol

Salmeterol

Salmeterol is a long-acting beta2-adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pu...
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Fingolimod (FTY720)

Fingolimod (FTY720)

FTY720 (Fingolimod, Gilenya) is a sphingosine-1-phosphate (S1P) receptor antagonist with IC50 of 0.033 nM. The inhibitory effect of S1P is revered by ...
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LY 341495

LY 341495

LY-341495 is a research drug  which acts as a potent and selective orthosteric antagonist for the group II metabotropic glutamate receptors (mGlu...
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Rotigotine (Neupro)

Rotigotine (Neupro)

Rotigotine (Neupro) is a non-ergoline dopamine agonist indicated for the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS) in Eur...
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Olmesartan (RNH6270, CS-088)

Olmesartan (RNH6270, CS-088)

Olmesartan is a prodrug that works by blocking the binding of angiotensin II to the AT1 receptors in vascular muscle; it is therefore independent of a...
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Sumanirole meleate (U95666E, PNU 95666)

Sumanirole meleate (U95666E, PNU 95666)

Sumanirole (PNU-95666) is a highly selective D2 receptor full agonist with an ED50 of about 46 nM, the first of its kind to be discovered. It was deve...
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SB 277011

SB 277011

SB-277011 is a drug which acts as a potent and selective dopamine D3 receptor antagonist, which is around 80-100x selective for D3 over D2, and lacks ...
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Org 27569 (ab120342)

Org 27569 (ab120342)

Org 27569 is a drug which acts as a potent and selective allosteric modulator of the cannabinoid CB1 receptor (pEC50 = 8.24). Studies in vitro suggest...
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