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Cabozantinib (XL-184)
XL184 (Cabozantinib) is a potent broad-spectrum tyrosine kinase inhibitor of VEGFR2 and c-Met with IC50 of 0.035 nM and 1.3 nM, respectively.XL-184 st...
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Pazopanib (GW786034)
Pazopanib Hydrochloride (GW786034, Votrient, Armala) is a novel multitargeted inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR, FGFR, c-Kit and c-fms wit...
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BAY 61-3606
Syk Inhibitor IV, BAY 61-3606 (BAY 61-3606) is a cell-permeable imidazopyrimidine compound that acts as a potent, ATP-competitive, reversible, and hig...
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E7080 (Lenvatinib)
E7080 (Lenvatinib) is the most potent dual inhibitor of VEGF-R3 tyrosine kinase (IC50=5.2 nM) as well as VEGF-R2 tyrosine kinase (IC50=4.0 nM) among t...
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Tivozanib (AV-951)
AV-951 (Tivozanib, KRN-951) is a potent and selective VEGFR inhibitor to all three VEGF receptors, VEGFR-1, -2 and -3 with IC50 of 0.21 nM, 0.16 nM an...
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TSU-68 (SU6688)
TSU-68 (SU6668, Orantinib) is a potent inhibitor to receptor tyrosine kinases Flk-1/KDR, PDGFRβ, and FGFR1, with Ki of 2.1 μM, 1.2 μM, and ...
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Cediranib (AZD-2171)
Cediranib (AZD2171) is a highly potent VEGFR2 inhibitor for VEGF-stimulated proliferation and KDR phosphorylation with IC50 of 0.4 nM and 0.5 nM, resp...
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Amuvatinib (MP 470)
MP-470 (Amuvatinib) is a potent and multi-targeted tyrosine kinase inhibitor that inhibits kinases including c-Kit and PDGFα, as well as their m...
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Motesanib Diphosphate (AMG-706)
Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM, 3 nM, 6 nM, 84 nM, 8 nM a...
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RAF 265 (CHIR 265)
RAF265 (CHIR-265) is an orally-bioavailable, selective, potent inhibitor of B-Raf and VEGFR-2 with IC50 of 3-60 nM and EC50 of 30 nM, respectively. B-...
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Sunitinib malate (Sutent)
Sunitinib malate (Sutent) is potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor (Ki values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PD...
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PD 173074
PD 173074 is a potent and selective inhibitor of FGFR tyrosine kinase activity, blocking autophosphorylation of FGFR1 with an IC50 value of 21.5 nM.Th...
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Regorafenib (BAY 73-4506)
Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioava...
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Brivanib (BMS 540215)
Brivanib (BMS-540215) is hydrolyzed to the active moiety BMS-540215 in vivo. BMS 540215 shows potent and selective inhibition of VEGFR and FGFR tyrosi...
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SU5402
SU 5402 is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1; ...
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