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A 922500
A-922500 is an orally, bioavailable human and mouse diacylglycerol acyltransferase DGAT-1 inhibitor (IC50 = 9nM and 22 nM, respectively), which may ta...
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BIX 01294
BIX-01294, a diazepin-quinazolinamine derivative, is a histone-lysine methyltransferase (HMTase) inhibitor that modulates the epigenetic status of chr...
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Tigecycline
Tigecycline is bacteriostatic and is a protein synthesis inhibitor by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of A...
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Mozavaptan
Mozavaptan is a vasopressin receptor antagonist. In Japan, it was approved for hyponatremia (low blood sodium levels) caused by syndrome of inappropri...
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Brinzolamide
Brinzolamide is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. [1][2]
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Isradipine
Isradipine (Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.It is usually prescribed for the treatment of high blood pressure...
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Posaconazole
Posaconazole (Noxafil) works by disrupting the close packing of acyl chains of phospholipids, impairing the functions of certain membrane-bound enzyme...
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Cidofovir
Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replicat...
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Imipenem
Imipenem is an intravenous β-lactam antibiotic developed in 1980. Imipenem has a broad spectrum of activity against aerobic and anaerobic, Gram-p...
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Brequinar (DUP 785, NSC 368390)
Brequinar (DUP-785, NSC-368390) inhibits dihydroorotate dehydrogenase (DHODH), the fourth enzyme in the de novo pyrimidine biosynthesis pathway, preve...
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Laquinimod
Laquinimod (ABR-215062) is an experimental immunomodulator developed by Active Biotech and Teva. It is currently being investigated as an oral treatme...
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Torcetrapib (CP 529414)
Torcetrapib (CP-529414) inhibits cholesterylester transfer protein (CETP) with an IC50 with 13 nM. Torcetrapib is a CETP inhibitor, and CETP normall...
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Loxiglumide
Loxiglumide (CRC-1505) is a small-molecule antagonist of the cholecystokinin receptor CCKA. Loxiglumide inhibits pancreatic secretion of digestive enz...
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Traxoprodil (CP-101606)
Traxoprodil (CP-101606) acts as an NMDA antagonist, selective for the NR2B subunit. It has neuroprotective, analgesic, and anti-Parkinsonian effects i...
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