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Rocilinostat (ACY 1215)

Rocilinostat (ACY 1215)

Rocilinostat, also known as ACY1215, is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic...
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EX 527

EX 527

Mammalian sirtuin 1 (SIR1) is a dinucleotide-dependent histone deacetylase (HDAC) with roles in energy metabolism and inflammation. EX 527 is a cell-p...
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Resminostat (4SC-201)

Resminostat (4SC-201)

Resminostat (4SC-201) is an orally administered histone deacetylase (HDAC) inhibitor for the treatment of cancers, which modifies the DNA structure of...
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Pemetrexed disodium (Alimta, LY 231514)

Pemetrexed disodium (Alimta, LY 231514)

Pemetrexed disodium (Alimta, LY-231514) is a novel antifolate and antimetabolite for TS, DHFR, and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respecti...
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Cytarabine (Cytosine)

Cytarabine (Cytosine)

Cytarabine (Cytosine) is an antimetabolic agent and DNA synthesis inhibitor with an IC50 of 16 nM in wild-type CCRF-CEM cells. [1][2]   Referen...
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Troxacitabine

Troxacitabine

Troxacitabine (Troxatyl) is a nucleoside analogue with anticancer activity. Its use is being studied in patients with refractory lymphoproliferative d...
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MS 275 (SNDX 275)

MS 275 (SNDX 275)

MS-275 (SNDX-275) is a HDAC inhibitor of HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, respectively. MS275 (SNDX275) binds to and inhibits hi...
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NSC 696085 (Pyroxamide)

NSC 696085 (Pyroxamide)

NSC-696085(Pyroxamide) inhibits histone deacetylases involved in transcription; induces hyperacetylation of core histones, modulating chromatin struct...
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HDAC inhibitor

HDAC inhibitor

Chemical Information Molecular Weight (WM): 611.61 ...
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MC 1568

MC 1568

MC1568 is a class II (IIa) selective HDAC inhibitor with IC50 of 220 nM. MC-1568 exhibits tissue-selective inhibition between members of class II acet...
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Nelarabine (Arranon)

Nelarabine (Arranon)

Nelarabine (Arranon, 506U78) is a purine nucleoside analog and DNA synthesis inhibitor for HSB2 cell lines and ALL-SIL cell lines with IC50 of 0.13 &m...
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Clofarabine

Clofarabine

Clofarabine is phosphorylated intracellularly to the cytotoxic active 5'-triphosphate metabolite, which inhibits the enzymatic activities of ribonucle...
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Exatecan

Exatecan

Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of ...
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CX 5461

CX 5461

CX-5461 is a potent small-molecule rRNA synthesis inhibitor with an IC50 of 0.11 μM. Deregulated ribosomal RNA synthesis is associated with uncontr...
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Trichostatin A (TSA)

Trichostatin A (TSA)

Trichostatin A (TSA) is a potent, reversible inhibitor of histone deacetylase (HDAC). In human Jurkat T cells, trichostatin A arrests cell cycle progr...
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Droxinostat (NS 41080)

Droxinostat (NS 41080)

Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8. Droxinostat shows comparable inhibition of HDAC6 and HDAC8 (IC50 = 2.47 and 1.46 μ...
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