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Product name : ABT 888 (Veliparib)
Item : cc346
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 912444-00-9
Molecular Weight : 244.29
Formula : C₁₃H₁₆N₄O
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
Veliparib (ABT 888) is a poly(ADP-ribose) polymerase (PARP) -1 and -2 inhibitor with Kis of 5.2 and 2.9 nM respectively. With no antiproliferative effects as a single agent at therapeutic concentrations, ABT-888 inhibits PARPs, thereby inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents. PARP nuclear enzymes are activated by DNA single or double strand breaks, resulting in the poly(ADP-ribosyl)ation of other nuclear DNA binding proteins involved in DNA repair; poly(ADP-ribosyl)ation contributes to efficient DNA repair and to survival of proliferating cells exposed to mild genotoxic stresses as induced by as oxidants, alkylating agents or ionizing radiation. [1][2]
 
Reference:
[1] Clin. Cancer Res. 2007, 13, 2728-2737.
[2] Clin. Cancer Res. 2012, 18, 1726-1734.
 
 
Chemical Information
Molecular Weight (WM):
244.29
Formula:
C13H16N4O
CAS No:
912444-00-9, 912445-05-7 (2HCl)
Purity:
≥ 98%
Synonyms:
ABT-888, ABT888
 
DMSO ≥ 49 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 6 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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