Product name : Panobinostat (LBH 589)
Item : cc487
Price : 2g, $650;5g, $1050; 10g $1650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 404950-80-7
Molecular Weight : 349.43
Formula : C₂₁H₂₃N₃O₂
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Panobinostat (LBH 589) selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2/M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. HDAC is an enzyme that deacetylates chromatin histone proteins. [1][2]
Reference:
[1] Blood 2009, 114, 5024-5033.
[2] Mol. Cancer Ther. 2009, 8, 2221-2231.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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