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Product name : Panobinostat (LBH 589)
Item : cc487
Price : 2g, $650;5g, $1050; 10g $1650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 404950-80-7
Molecular Weight : 349.43
Formula : C₂₁H₂₃N₃O₂
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
Panobinostat (LBH 589) selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2/M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. HDAC is an enzyme that deacetylates chromatin histone proteins. [1][2]
 
Reference:
[1] Blood 2009, 114, 5024-5033.
[2] Mol. Cancer Ther. 2009, 8, 2221-2231.
 
 
Chemical Information
Molecular Weight (WM):
349.43
Formula:
C21H23N3O2
CAS No:
404950-80-7
Purity:
≥ 98%
Synonyms:
LBH589, LBH-589, NVP-LBH589
 
DMSO ≥ 70 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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