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Products > DNA damage > HDAC > PCI 24781 (CRA 02478)
Product name : PCI 24781 (CRA 02478)
Item : cc488
Price : 200mg, $750;500mg, $1250; 1g $1950; 2g, $3050
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 783355-60-2
Molecular Weight : 397.42
Formula : C₂₁H₂₃N₃O₅
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
Abexinostat (PCI-24781 or CRA-024781) is novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. PCI-24781 inhibited pure recombinant HDAC1 with a Ki of 0.007 Mmol/L, and also inhibited the other HDAC isozymes HDAC2, HDAC3/SMRT, HDAC6, HDAC8, and HDAC10 in the nanomolar range. ]Abexinostat inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; and the tumor suppressor protein-mediated inhibition of tumor cell division and induction of tumor cell apoptosis. HDAC, upregulated in many tumor types, is an an enzyme that is responsible for the deacetylation of chromatin histone proteins. [1][2]
  
Reference:
[1] Mol. Cancer Ther. 2006, 5, 1309-1317.
[2] Clin. Cancer Res. 2009, 15, 3472-3483.
 
  
Chemical Information
Molecular Weight (WM):
397.42
Formula:
C21H23N3O5
CAS No:
783355-60-2
Purity:
≥ 98%
Synonyms:
PCI24781, PCI-24781, CRA024781
 
DMSO ≥ 80 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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