Apoptosis
DHFR
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Product name : YK-4-279
Item : c2370
Price : 200mg, $659;500mg, $1150; 1g, $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com
CAS : 1037184-44-3
Molecular Weight : 366.194
Formula : C17H13Cl2NO
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order.
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| Details: |
Description of:YK-4-279
YK-4-279(cas:1037184-44-3)is a ETV1 inhibitor, which inhibitor protein-protein interactions between ES-FLI1 and RHA.YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model. YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1. YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft model. Quality control data: Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS. Product will be shipped with supporting analytical data. REFERENCES[1]. Barber-Rotenberg JS, et al. Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1. Oncotarget. 2012 Feb;3(2):172-82.[2]. Rahim S, et al. YK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasion. PLoS One. 2011 Apr 29;6(4):e19343. [3]. Erkizan HV, et al. A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma. Nat Med. 2009 Jul;15(7):750-6. |
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