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Products > DNA damage > HDAC > Belinostat (PXD 101)
Product name : Belinostat (PXD 101)
Item : cc489
Price : , $650;5g, $1050; 10g $1650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 866323-14-0
Molecular Weight : 318.35
Formula : C₁₅H₁₄N₂O₄S
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
Belinostat (PXD 101) inhibits HDAC activity in HeLa cell extracts with an IC50 of 27 nM. It targets tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase. [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2003, 2, 721-728.
[2] Clin. Cancer Res. 2008, 14, 804-810.
 
 
Chemical Information
Molecular Weight (WM):
318.35
Formula:
C15H14N2O4S
CAS No:
414864-00-9
Purity:
≥ 98%
Synonyms:
PXD101, PXD-101. PX105684
 
DMSO ≥ 64 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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