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Product name : Mocetinostat (MGCD 0103)
Item : cc119
Price : 10mg, $275; 50mg, $715; 100mg, $1295; 200mg, $2295
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
Mocetinostat (MGCD0103) is a potent HDAC inhibitor with IC50 of 15, 0.29, 1.66 μM for HDAC 1, HDAC 2 and HDAC 3, respectively. It binds to and inhibits Class 1 isoforms of HDAC, specifically HDAC 1, 2 and 3, which may result in epigenetic changes in tumor cells and so tumor cell death; although the exact mechanism has yet to be defined, tumor cell death may occur through the induction of apoptosis, differentiation, cell cycle arrest, inhibition of DNA repair, upregulation of tumor suppressors, down regulation of growth factors, oxidative stress, and autophagy, among others. Overexpression of Class I HDACs 1, 2 and 3 has been found in many tumors and has been correlated with a poor prognosis. [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2008, 7, 759-768.
[2] Science 2011, 102, 1201-1207.
 
 
Chemical Information
Molecular Weight (WM):
396.44
Formula:
C23H20N6O
CAS No:
726169-73-9
Purity:
≥ 98%
Synonyms:
MGCD-0103, MGCD0103
 
DMSO ≥ 13 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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