Apoptosis
Telomerase
|
Product name : YM 201636
Item : cc386
Price : 200mg, $450;500mg, $850; 1g $1250; 2g, $1850
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 371942-69-7
Molecular Weight : 467.48
Formula : C₂₅H₂₁N₇O₃
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
 |
| Details: | |||||||||||||||||||||||||
YM 201636 is an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, can halt glucose entry by insulin in adipocytes. YM201636 almost completely inhibited basal and insulin-activated 2-deoxyglucose uptake at doses as low as 160 nM, with IC50 of 54 nM for the net insulin response. Insulin-induced GLUT4 translocation was partially inhibited at substantially higher doses, comparable to those required for inhibition of insulin-induced phosphorylation of Akt/PKB. In addition to PIKfyve, YM201636 also completely inhibited insulin-dependent activation of class IA PI 3-kinase. [1][2]
Reference:
[1] Int. J Cell Biol. 2012, 2012, 179207.
[2] J Biol. Chem. 2011, 286, 32105-32114.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
|
| Related Products : |
|
|
|
|
||||||||
|
|
|
|
Chinese
Deutsch
Espanol
Francais
Italiano
Portugues
Japanese
Korean
Arabic
Russian