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Product name : TG100-115
Item : cc492
Price : 10mg, $225; 50mg, $695; 100mg, $895; 200mg, $1475
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
TG100-115, inhibited PI3K γ and -δ(IC50 values of 83 and 235 nM, respectively), whereas both PI3Kα and -β were relatively unaffected (IC50 values>1 μM). As a gauge of general specificity, TG100-115 was also assayed against a 133 protein kinase panel, none of which was inhibited at IC50 values <1 μM.

TG100-115 is applied to anti-inflammatory therapy for respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). TG100-115 could reduce inflammation and mucin accumulation. [1][2]
 
Reference:
[1] J Pharmacol. Exp. Ther. 2009, 328, 758-765.
[2] Biochem. Soc. Trans. 2007, 35, 204-206.
 
 
Chemical Information
Molecular Weight (WM):
346.34
Formula:
C18H14N6O2
CAS No:
677297-51-7
Purity:
≥ 98%
Synonyms:
TG100115, TG100 115
 
DMSO ≥ 9 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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