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Product name : IC 87114
Item : cc493
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS :  371242-69-2
Molecular Weight : 397.43
Formula : C₂₂H₁₉N₇O
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
IC 87114 is a cell permeable, selective inhibitor of PI 3-Kδ (IC50= 1.82, 0.07, and 1.24 for p110b, p110d, and p110g, respectively, but may also target p110a at concentrations as high as 100 µM with less potency) in NB-4 and primary APL cells. It has been reported that the constitutive activation of PI3K/Akt signaling in primary AML cells is predominantly attributable to PI 3-Kδ. Pharmacologic use of PI 3-Kδ inhibitor has been shown to block PI3K/Akt/mTOR signaling and could thereby reduce proliferation and induce apoptosis. A related study further suggests PI 3-Kδ inhibitor as a key therapeutic target among PI 3-K isoforms for allergy- and mast cell-related diseases. [1][2]
 
Reference:
[1] Oncogene 2005, 25, 6648-6659.
[2] Biochimica. Et Biophyscia Acta. 2008, 1784, 159-185.
 
 
Chemical Information
Molecular Weight (WM):
397.43
Formula:
C22H19N7O
CAS No:
371242-69-2
Purity:
≥ 98%
Synonyms:
IC87114, IC-87114
 
DMSO ≥ 5 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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