Apoptosis
Telomerase
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Product name : GSK 2126458
Item : cc65
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1086062-66-9
Molecular Weight : 505.5
Formula : C₂₅H₁₇F₂N₅O₃S
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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GSK 2126458 is a highly potent PI3K and mTOR inhibitor with an app Ki of 19 pM for PI3K. GSK 2126458 binds to and inhibits PI3K in the PI3K/mTOR signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability and inducing apoptotic cell death. Bax is a member of the proapoptotic Bcl2 family of proteins. PI3K, often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival. [1][2]
Reference:
[1] ACS Med. Chem. Lett. 2010, 1, 39-43.
[2] Cancer Biol. Ther. 2011, 11, 938-946.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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