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Product name : GSK 2126458
Item : cc65
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1086062-66-9
Molecular Weight : 505.5
Formula : C₂₅H₁₇F₂N₅O₃S
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
GSK 2126458 is a highly potent PI3K and mTOR inhibitor with an app Ki of 19 pM for PI3K. GSK 2126458 binds to and inhibits PI3K in the PI3K/mTOR signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability and inducing apoptotic cell death. Bax is a member of the proapoptotic Bcl2 family of proteins. PI3K, often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival. [1][2]
 
Reference:
[1] ACS Med. Chem. Lett. 2010, 1, 39-43.
[2] Cancer Biol. Ther. 2011, 11, 938-946.
 
 
Chemical Information
Molecular Weight (WM):
505.50
Formula:
C25H17F2N5O3S
CAS No:
1086062-66-9
Purity:
≥ 98%
Synonyms:
GSK2126458, GSK-2126458
 
DMSO ≥ 101 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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