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Product name : PKI 587 (PF-05212384)
Item : cc54
Price : 200mg, $650;500mg, $1050; 1g $1650; 2g, $2450
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1197160-78-3
Molecular Weight : 615.73
Formula : C₃₂H₄₁N₉O₄
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
PKI 587 (PF-05212384) is highly potent dual PI3K/mTOR kinase inhibitor with IC50 of 0.4 nM and < 0.1 μM for PI3K-α and mTOR, respectively. Upon intravenous administration, PI3K/mTOR kinase inhibitor PKI-587 inhibits both PI3K and mTOR kinases, which may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K. [1][2]
 
Reference:
[1] Clin. Cancer Res. 2011, 17, 193-203.
[2] J Med. Chem. 2010, 53, 2636-2645.
 
 
Chemical Information
Molecular Weight (WM):
615.73
Formula:
C32H41N9O4
CAS No:
1197160-78-3
Purity:
≥ 98%
Synonyms:
PKI587, PKI-587, PF-05212384
 
DMSO ≥ 9 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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