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Product name : XL 765 (SAR 245409)
Item : cc497
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 934493-76-2
Molecular Weight : 270.29
Formula : C₁₃H₁₄N₆O
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
XL 765(SAR 245409) is a mixed mTOR/PI3k inhibitor with IC50 of 157, 39, 113, 9 and 43 nM for mTOR, p110α, β, γ and δ, respectively. PI3K/mTOR dual kinase inhibitor XL765 inhibits both PI3K kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in susceptible tumor cell populations. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated in a PI3K-independent fashion in response to nutrient and energy deprivation. Accordingly, this agent maybe more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone. [1][2] 
 
Reference:
[1] Oncogene 2008, 27, 5511-5526.
[2] http://www.exelixis.com/pipeline/xl765
 
 
Chemical Information
Molecular Weight (WM):
599.66
Formula:
C31H29N5O6S
CAS No:
1123889-87-1
Purity:
≥ 98%
Synonyms:
SAR245409, XL765, XL-765, SAR-245409
 
DMSO ≥ 15 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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