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Product name : XL 147
Item : cc43
Price : 200mg, $650;500mg, $1050; 1g $1650; 2g, $2450
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : We offer significant discount for larger quantity order
Molecular Weight : 541.02
Formula : C₂₅H₂₅ClN₆O₄S
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
XL147 reversibly binds to class 1 PI3Ks in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K signaling pathway; this may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents including genotoxic agents and receptor tyrosine kinase inhibitors. [1][2]
  
Reference:
[1] http://www.exelixis.com/pipeline/xl147.
[2] Proc. Natl. Acad. Sci. USA. 2012, 109, 2718-2723.
 
 
Chemical Information
Molecular Weight (WM):
448.53
Formula:
C21H16N6O2S2
CAS No:
956958-53-5
Purity:
≥ 98%
Synonyms:
XL147, XL-147
 
DMSO ≥ 89 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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