Apoptosis
Telomerase
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Product name : PIK 75
Item : cc499
Price : 200mg, $650;500mg, $1050; 1g $1650; 2g, $2450
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 372196-77-5
Molecular Weight : 488.74
Formula : C₁₆H₁₅BrClN₅O₄S
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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PIK-75 Hydrochloride is a hydrochloride salt form of PIK-75, which is a preferential p110α/γ forms of PI3K inhibitor with IC50 of 6, 1300, 76, 510 nM for p110α, p110β, p110γ, p110δ, respectively. PIK-75 is a PI3K p110α specific inhibitor and belongs to the class of imidazo[1, 2-a]pyridines. It inhibited cell proliferation of A375 cells (IC50=58nM) in vitro and reduced tumor growth in a mouse xenograft model. Besides inhibition of PI3Kα, PIK-75 also inhibited DNA-PK with an IC50 of 2 nM, but not mTORC1 and mTORC2. PIK-75-mediated anti-inflammatory effects are associated with dramatic inhibition of AKT phosphorylation, IKK activation and NF-κB transcription. [1][2]
Reference:
[1] Biochem Biophys Res Commun. 2009, 379, 830-834.
[2] Am. J Physiol. Cell Physiol. 2010, 298, c929-941.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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