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Product name : PIK 75
Item : cc499
Price : 200mg, $650;500mg, $1050; 1g $1650; 2g, $2450
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 372196-77-5
Molecular Weight : 488.74
Formula : C₁₆H₁₅BrClN₅O₄S
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
PIK-75 Hydrochloride is a hydrochloride salt form of PIK-75, which is a preferential p110α/γ forms of PI3K inhibitor with IC50 of 6, 1300, 76, 510 nM for p110α, p110β, p110γ, p110δ, respectively. PIK-75 is a PI3K p110α specific inhibitor and belongs to the class of imidazo[1, 2-a]pyridines. It inhibited cell proliferation of A375 cells (IC50=58nM) in vitro and reduced tumor growth in a mouse xenograft model. Besides inhibition of PI3Kα, PIK-75 also inhibited DNA-PK with an IC50 of 2 nM, but not mTORC1 and mTORC2. PIK-75-mediated anti-inflammatory effects are associated with dramatic inhibition of AKT phosphorylation, IKK activation and NF-κB transcription. [1][2]
 
Reference:
[1] Biochem Biophys Res Commun. 2009, 379, 830-834.
[2] Am. J Physiol. Cell Physiol. 2010, 298, c929-941.
 
 
Chemical Information
Molecular Weight (WM):
488.74
Formula:
C16H14BrN5O4S·HCl
CAS No:
372196-77-5
Purity:
≥ 98%
Synonyms:
PIK-75, PIK75
 
DMSO ≥ 18 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 5 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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