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Product name : A 66
Item : c500
Price : 200mg, $950;500mg, $1650; 1g $2450; 2g, $3650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS :  1166227-08-2
Molecular Weight : 393.53
Formula : C₁₇H₂₃N₅O₂S₂
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
A66 is a novel small molecule inhibitor of PI3K p110α with IC50 values of 32, 30 and 43 nM for p110α, p110α/E545K and p110α/H1047R. A66, showing the S-enantiomer to be a highly specific and selective p110α inhibitor. The responsive cell lines all harboured H1047R mutations in PIK3CA and have high levels of p110α and class-Ia PI3K activity. A66 is more than 100 fold less active against the other class-I PI 3-kinase isoforms and had not inhibitory activity against 200 protein kinases when tested at 10 micromolar. This makes it the most selective and specific p110α inhibitor available for research purposes. [1][2]
 
Reference:
[1] Biochem. J 2011, 428, 53-62.
[2] Proc. Natl. Acad. Sci. USA. 2010, 107, 15547-15552.
 
 
Chemical Information
Molecular Weight (WM):
393.53
Formula:
C17H23N5O2S2
CAS No:
1166227-08-2
Purity:
≥ 98%
Synonyms:
A66, A-66
 
DMSO ≥ 79 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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