Apoptosis
Telomerase
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Product name : NVP-BKM120 (BKM 120)
Item : cc258
Price : 2g, $650;5g, $1050; 10g $1650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 944396-07-0
Molecular Weight : 410.39
Formula : C₁₈H₂₁F₃N₆O₂
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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NVP-BKM120 efficiently blocks constitutive activation of PI3K/AKT pathway in FL cells, and completely abrogates AKT activation derived from co-culture with BM stromal cells or FDCs or consequent to BCR ligation. NVP-BKM120 interferes with tumor cell-microenvironment interactions by blocking SDF1α/CXCL12-induced migration and significantly reduces the secretion of several cytokines (p<0.01), including GM-CSF, G-CSF, CCL2, CCL7, CCL8, IL1, IL7, IL8 and IL10 in a FL-FDC co-culture model. [1][2]
Reference:
[1] ACS Med. Chem. Lett. 2011, 2, 774-779.
[2] Cancer Res. 2012, 72, LB-361.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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