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Product name : NVP-BKM120 (BKM 120)
Item : cc258
Price : 10mg, $225; 50mg, $875; 100mg, $1275; 200mg, $2175
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
NVP-BKM120 efficiently blocks constitutive activation of PI3K/AKT pathway in FL cells, and completely abrogates AKT activation derived from co-culture with BM stromal cells or FDCs or consequent to BCR ligation. NVP-BKM120 interferes with tumor cell-microenvironment interactions by blocking SDF1α/CXCL12-induced migration and significantly reduces the secretion of several cytokines (p<0.01), including GM-CSF, G-CSF, CCL2, CCL7, CCL8, IL1, IL7, IL8 and IL10 in a FL-FDC co-culture model.  [1][2]
 
Reference:
[1] ACS Med. Chem. Lett. 2011, 2, 774-779.
[2] Cancer Res. 2012, 72, LB-361.
 
 
Chemical Information
Molecular Weight (WM):
410.39
Formula:
C18H21F3N6O2
CAS No:
944396-07-0, 1312445-63-8 (HCl)
Purity:
≥ 98%
Synonyms:
BKM120, BKM-120, BKM 120
 
DMSO ≥ 82 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 25 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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