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Product name : ZSTK 474
Item : cc503
Price : 200mg, $850;500mg, $1450; 1g $2250; 2g, $3350
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 475110-96-4
Molecular Weight : 417.41
Formula : C₁₉H₂₁F₂N₇O₂
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
ZSTK474 is an inhibitor of PI3K γ (IC50 at 6 nM). This agent inhibits PI3K α and PI3K β with IC50 of 17 and 53 nM, respectively. Western blot analysis showed enhanced phosphorylation of Akt and GSK-3β by X-irradiation, whereas phosphorylation was inhibited by ZSTK474 treatment alone. Treatment with ZSTK474 after X-irradiation also inhibited phosphorylation, and remarkably inhibited xenograft tumor growth. Combined treatment with X-rays and ZSTK474 has greater therapeutic potential than radiation or drug therapy alone, both in vitro and in vivo. [1][2]
 
Reference:
[1] Bioorg. Med. Chem. 2012, 20, 1947-1951.
[2] Biochem. J 2012, 442, 161-169.
 
 
Chemical Information
Molecular Weight (WM):
417.41
Formula:
C19H21F2N7O2
CAS No:
475110-96-4
Purity:
≥ 98%
Synonyms:
ZSTK-474, ZSTK 474
 
DMSO ≥ 21 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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