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Product name : NVP-BEZ235 (BEZ 235)
Item : cc442
Price : 200mg, $450;500mg, $850; 1g $1250; 2g, $1850
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 915019-65-7
Molecular Weight : 469.54
Formula : C₃₀H₂₃N₅O
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
NVP-BEZ235 is a potent dual inhibitor of PI3K and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anticancer agents when used in in vivo combination studies. It inhibits PI3K isoforms and mutants with low nanomolar IC50 values, leading to growth arrest in the G1 phase. Through its effects on PI3K, NVP-BEZ235 inhibits VEGF-induced angiogenesis. By directly blocking cell growth and indirectly inhibiting angiogenesis, it has potential in both solid tumors and in metastatic melanoma therapy. [1][2]
 
Reference:
[1] Oncotarget 2010, 1, 578-582.
[2] Leuk. Res. 2012, 36, 912-920.
 
 
Chemical Information
Molecular Weight (WM):
469.55
Formula:
C30H23N5O
CAS No:
915019-65-7, 1028385-32-1 (4-methylbenzenesulfonate)
Purity:
≥ 98%
Synonyms:
BEZ-235, BEZ235, BEZ 235
 
DMSO ≥ 7 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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