Apoptosis
Telomerase
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Product name : GDC 0980 (RG7422)
Item : cc6
Price : 200mg, $750;500mg, $1250; 1g $1950; 2g, $3050
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1032754-93-0
Molecular Weight : 498.6
Formula : C₂₃H₃₀N₈O₃S
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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GDC 0980 (RG7442) shows the potent and selective inhibitory activities against class I PI3K and mTOR kinase versus a large panel of kinases with Ki of 17 nM for mTOR and IC50 of 5 nM, 27 nM, 7 nM, and 14 nM for PI3Kα, β, δ, and γ, respectively. In vitro, GDC-0980 significantly inhibits cell proliferation in PC3 and MCF7 cells with IC50 of 307 nM and 255 nM, respectively. A recent study shows that GDC-0980 reduces cancer cell viability by inhibiting cell-cycle procession and inducing apoptosis with most potency in prostate (IC50 < 200 nM 50%), <500 nM 100%), breast (IC50 <200 nM 37%, <500 nM 78%) and NSCLC lines (IC50 <200 nM 29%, <500 nM 88%) and less potency in pancreatic (IC50 <200 nM 13%, <500 nM 67%) and melanoma cell lines (IC50 <200 nM 0%, <500 nM 33%). [1][2]
Reference:
[1] J Med. Chem. 2011, 54, 7579-7587.
[2] Mol. Cancer Ther. 2011, 10, 2426-2436.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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