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Product name : MK 2206
Item : cc295
Price : 200mg, $450;500mg, $850; 1g $1250; 2g, $1850
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1032350-13-2
Molecular Weight : 480.39
Formula : C₂₅H₂₃Cl₂N₅O
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
MK 2206 is an Akt inhibitor, is also an orally bioavailable allosteric inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor MK2206 binds to and inhibits the activity of Akt in a non-ATP competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. [1][2]
 
Reference:
[1] J Med. Chem. 2010, 53, 1413-1437.
[2] J Clin. Endocrinol. Metab. 2011, 96, E577-585.
 
 
Chemical Information
Molecular Weight (WM):
480.39
Formula:
C25H21N5O·HCl
CAS No:
1032350-13-2
Purity:
≥ 98%
Synonyms:
MK-2206, MK2206
 
DMSO ≥ 96 mg/mL
Solubility (25℃)
Water ≥ 96 mg/mL
 
Ethanol ≥ 2 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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