Apoptosis
Telomerase
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Product name : GSK 690693
Item : cc44
Price : 200mg, $750;500mg, $1250; 1g $1950; 2g, $3050
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 937174-76-0
Molecular Weight : 425.48
Formula : C₂₁H₂₇N₇O₃
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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GSK-690693 binds to and inhibits Akt kinases 1, 2, and 3 with IC50 values of 1, 13, 9 nM respectively, which may result in the inhibition of protein phosphorylation events downstream from Akt kinases in the PI3K/Akt signaling pathway, and, subsequently, the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. In addition, this agent may inhibit other protein kinases including protein kinase C (PKC) and protein kinase A (PKA). As serine/threonine protein kinases which are involved in a number of biological processes, AKT kinases promote cell survival by inhibiting apoptosis and are required for glucose transport.[1][2]
Reference:
[1] J Med. Chem. 2008, 51, 5663-5679.
[2] Blood 2009, 113, 1723-1729.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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