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Product name : GSK 690693
Item : cc44
Price : 200mg, $750;500mg, $1250; 1g $1950; 2g, $3050
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 937174-76-0
Molecular Weight : 425.48
Formula : C₂₁H₂₇N₇O₃
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
GSK-690693 binds to and inhibits Akt kinases 1, 2, and 3 with IC50 values of 1, 13, 9 nM respectively, which may result in the inhibition of protein phosphorylation events downstream from Akt kinases in the PI3K/Akt signaling pathway, and, subsequently, the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. In addition, this agent may inhibit other protein kinases including protein kinase C (PKC) and protein kinase A (PKA). As serine/threonine protein kinases which are involved in a number of biological processes, AKT kinases promote cell survival by inhibiting apoptosis and are required for glucose transport.[1][2]
  
Reference:
[1] J Med. Chem. 2008, 51, 5663-5679.
[2] Blood 2009, 113, 1723-1729.
 
 
Chemical Information
Molecular Weight (WM):
425.48
Formula:
C21H27N7O3
CAS No:
937174-76-0
Purity:
≥ 98%
Synonyms:
GSK-690693, GSK690693
 
DMSO ≥ 39 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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