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Product name : TWS 119
Item : cc510
Price : 200mg, $450;500mg, $850; 1g $1250; 2g, $1850
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 601514-19-6
Molecular Weight : 318.33
Formula : C₁₈H₁₄N₄O₂
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
TWS 119 is a cell-permeable pyrrolopyrimidine compound that acts as a potent inhibitor of GSK-3β (IC50 = 30 nM). TWS119 binds to GSK-3β with high-affinity (Kd = 126 nM) and increases the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. It is shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM). [1][2]
 
Reference:
[1] Proc. Natl. Acad. Sci. USA. 2003, 100, 7632-7637.
[2] Biochem. Biophys. Res. Commun. 2010, 391, 1049-1055.
 
 
Chemical Information
Molecular Weight (WM):
318.33
Formula:
C18H14N4O2
CAS No:
601514-19-6
Purity:
≥ 98%
Synonyms:
TWS-119
 
DMSO ≥ 64 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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