Apoptosis
Telomerase
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Product name : A 674563
Item : cc293
Price : 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 552325-73-2
Molecular Weight : 358.44
Formula : C₂₂H₂₂N₄O
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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A-674563 is a potent selective protein kinase B/Akt inhibitor with an IC50 of 14 nM. A674563 also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively. While promising efficacy was observed in vivo, A-674563 indicated significantly effects on depolarization of purkinje fiber in an in vitro assay and severe CV toxicity (e.g. hypotension) in vivo. An X-ray structure of A 674563 bound to protein kinase A, which has 80% homology with Akt in the kinase domain, suggested the phenyl group is not tightly bound in the ligand-protein complex. The Akt inhibitor A-674563 displayed proliferation of tumor cells with an EC50 of 0.4 μM. When given in combination, A-674563 enhanced the efficacy of paclitaxel in a PC-3 xenograft model. [1][2]
Reference:
[1] Mol. Cancer Res. 2005, 4, 977-986.
[2] Mini Review in Medicinal Chemistry, 2011, 11, 1093-1107.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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