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Product name : NSC 74859 (S3I-201)
Item : cc515
Price : 200mg, $450;500mg, $850; 1g $1250; 2g, $1850
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 501919-59-1
Molecular Weight : 365.36
Formula : C₁₆H₁₅NO₇S
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
NSC 74859 (S3I-210) is a cell-permeable amidosalicylic acid compound that binds Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription. S3I-201 inhibits Stat3-Stat3 complex formation and Stat3 DNA-binding (IC50 =86±33μM) and transcriptional activities. Furthermore, S3I201 inhibits growth and induces apoptosis preferentially in tumor cells that contain persistently activated Stat3.  [1][2]
 
Reference:
[1] Proc. Natl. Acad. Sci. USA 2007, 104, 7391-7396.
[2] Oncogene 2009, 28, 961-972.
 
 
Chemical Information
Molecular Weight (WM):
365.36
Formula:
C16H15NO7S
CAS No:
501919-59-1
Purity:
≥ 98%
Synonyms:
S3I 201, NSC-74859, NSC74859
 
DMSO ≥ 73 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 3 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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