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Product name : AZD 1480
Item : cc358
Price : 200mg, $750;500mg, $1250; 1g $1950; 2g, $3050
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 935666-88-9
Molecular Weight : 348.77
Formula : C₁₄H₁₄ClFN₈
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
AZD1480 is an orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with an IC50 of 0.26 nM. JAK2 inhibitor AZD1480 inhibits JAK2 activation, leading to the inhibition of the JAK/STAT (signal transducer and activator of transcription) signaling including activation of STAT3. This may lead to induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival.  [1][2]
 
Reference:
[1] Cancer Res. 2011, 71, 6601-6610.
[2] J Med. Chem. 2011, 54, 262-276.
 
 
Chemical Information
Molecular Weight (WM):
348.77
Formula:
C14H14ClFNO8
CAS No:
935666-88-9, 1260222-79-4 (TFA)
Purity:
≥ 98%
Synonyms:
AZD-1840, AZD 1840
 
DMSO ≥ 70 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 5 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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