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Product name : Tofacitinib (CP-690550)
Item : cc396
Price : 10mg, $75, 50mg, $245; 100mg, $345; 200mg, $595
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
Tofacitinib (Tasocitinib, CP-690550) is a novel, small molecule inhibitor of JAK3 with an IC50 with 1 nM, and exhibits rather indiscriminate activity towards JAK1 (IC50 = 112 nM) and JAK2 (IC50 = 20 nM). CP 690550 is an inhibitor of the enzyme Janus kinase 3 (JAK3), which means that it interferes with the JAK-STAT signaling pathway that transmits information outside the cell into the cell nucleus, influencing DNA transcription. Recently it has been shown in a murine model of established arthritis, tofacitinib rapidly improved disease by inhibiting the production of inflammatory mediators and suppressing STAT1-dependent genes in joint tissue. This efficacy in this disease model correlated with the inhibition of both JAK1 and 3 signaling pathways, suggesting that tofacitinib may exert therapeutic benefit via pathways that are not exclusive to inhibition of JAK3. [1][2]
 
Reference:
[1] Science 2003, 302, 875-878.
[2] Eur. J Pharmacol. 2008, 582, 154-161.
 
 
Chemical Information
Molecular Weight (WM):
312.37
Formula:
C16H20N6O
CAS No:
477600-75-2, 540737-29-9 (citrate)
Purity:
≥ 98%
Synonyms:
Tasobitinib, CP-690550, CP690550
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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