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Product name : LY 2784544
Item : cc18
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1229236-86-5
Molecular Weight : 469.94
Formula : C₂₃H₂₅ClFN₇O
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
LY2784544 is a small molecule selective mutant JAK2 kinase inhibitor with an IC50 of 68 nM. The antiproliferative activity of LY2784544 and its ability to induce apoptosis were examined by Celltiter-Glo Cell Viability and Caspase-Glo 3/7 Apoptosis Assays, respectively.  In the in vitro tests using Ba/F3 cells expressing either wild type or V617F mutant JAK2, LY-2784544 potently inhibited the JAK2 V617F-STAT5 signaling at a concentration that was 41-fold lower than that required to inhibit IL-3-activated wild type JAK2-STAT5 signaling (IC50 = 0.055 µM for JAK2 V617F vs. 2.26 µM for WT JAK2). Similarly in the proliferation assay, LY 2784544 selectively inhibited the JAK2 V617F-driven cell proliferation (IC50= 0.068 µM). Inhibition of JAK2 V617F signaling correlated well with the induction of apoptosis (EC50= 0.113 µM) in Ba/F3 cell model. [1][2]
 
Reference:
[1] Curr. Hematol. Malig. Rep. 2010, 5, 15-21..
[2] Curr. Opin. Hematol. 2012, 19, 11-123.
 
 
Chemical Information
Molecular Weight (WM):
469.94
Formula:
C23H25ClFN7O
CAS No:
1229236-86-5
Purity:
≥ 98%
Synonyms:
LY-2784544
 
DMSO ≥ 94 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 9 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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