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Product name : CYT 387 (CYT11387)
Item : cc203
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1056634-68-4
Molecular Weight : 414.46
Formula : C₂₃H₂₂N₆O₂
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
CYT 387 is an orally bioavailable small-molecule inhibitor of Janus kinases 1 and 2 (JAK1/2) with IC50 of 11 and 18 nM respectively. CYT387 competes with JAK1/2 for ATP binding, which may result in inhibition of JAK1/2 activation, inhibition of the JAK-STAT signaling pathway, and so the induction of apoptosis and a reduction of tumor cell proliferation in JAK1/2-expressing tumor cells. JAK2 is the most common mutated gene in bcr-abl-negative myeloproliferative disorders; the JAK2V617F gain-of-function mutation involves a valine-to-phenylalanine modification at position 617. The JAK-STAT signaling pathway is a major mediator of cytokine activity and is often dysregulated in a variety of tumor cell types. [1][2]
 
Reference:
[1] Leukemia 2009, 23, 1441-1445.
[2] Blood 2010, 115, 5232-5240.
 
 
Chemical Information
Molecular Weight (WM):
414.46
Formula:
C23H22N6O2
CAS No:
1056634-68-4
Purity:
≥ 98%
Synonyms:
CYT 11387, CYT-11387, CYT11387
 
DMSO ≥ 83 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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