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Product name : TG 101209
Item : cc108
Price : 10mg, $275; 50mg, $765; 100mg, $1295; 200mg, $2195
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 936091-14-4
Molecular Weight : 509.67
Formula : C₂₆H₃₅N₇O₂S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
TG101209 is a potent and small molecule JAK2-selective kinase inhibitor with IC50 of 6, 25, 17 and 169 nM for JAK2, FLT3, RET and JAK3, respectively. TG-101209 inhibited growth of Ba/F3 cells expressing JAK2V617F or MPLW515L mutations with an IC(50) of approximately 200 nM. In a human JAK2V617F-expressing acute myeloid leukemia cell line, TG101209-induced cell cycle arrest and apoptosis, and inhibited phosphorylation of JAK2V617F, STAT5 and STAT3. Therapeutic efficacy of TG 101209 was demonstrated in a nude mouse model. Furthermore, TG101209 suppressed growth of hematopoietic colonies from primary progenitor cells harboring JAK2V617F or MPL515 mutations. [1][2]
 
Reference:
[1] Leukemia 2007, 21, 1658-1668.
[2] Am. J Hematol. 2010, 85, 675-686.
 
  
Chemical Information
Molecular Weight (WM):
509.67
Formula:
C26H35N7O2S
CAS No:
936091-14-4
Purity:
≥ 98%
Synonyms:
TG-101209
 
DMSO ≥ 102 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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