Favorite  |  Set Home
Products > JAK/STAT > JAK > TG 101348
Product name : TG 101348
Item : cc67
Price : 200mg, $449;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 936091-26-8
Molecular Weight : 524.68
Formula : C₂₇H₃₆N₆O₃S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
TG101348 (SAR302503) is an orally available inhibitor of Janus kinase 2 (JAK-2) developed for the treatment of patients with myeloproliferative diseases including myelofibrosis. TG-101348 acts as a competitive inhibitor of protein kinase JAK-2 with IC50=6 nM; related kinases FLT3 and RET are also sensitive, with IC50=25 nM and IC50=17 nM, respectively. Significantly less activity was observed against other tyrosine kinases including JAK3 (IC50=169 nM). In treated cells the inhibitor blocks downstream cellular signalling (JAK-STAT) leading to suppression of proliferation and induction of apoptosis.[1][2]
 
Reference:
[1] Leukemia 2008, 22, 1790-1792.
[2] Cancer Cell 2008, 14, 311-320.
 
 
Chemical Information
Molecular Weight (WM):
524.68
Formula:
C27H36N6O3S
CAS No:
936091-26-8
Purity:
≥ 98%
Synonyms:
TG 101348, SAR-302503, SAR 302503
 
DMSO ≥ 105 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 42 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

Related Products :
WP 1066
WP 1066
Price: 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
TG 101209
TG 101209
Price: 10mg, $275; 50mg, $765; 100mg, $1295; 200mg, $2195
Tofacitinib (CP-690550)
Tofacitinib (CP-690550)
Price: 200mg, $450;500mg, $850; 1g $1250; 2g, $1850
Oclacitinib
Oclacitinib
Price: 200mg, $950;500mg, $1695; 1g, $2490; 2g, $3590
Upadacitinib (Synonyms: ABT-494)
Upadacitinib (Synonyms: ABT-494)
Price: 200mg, $1750;500mg, $2890; 1g, $3950;
Lestaurtinib
Lestaurtinib
Price: out of stock
Ruxolitinib (INCB018424)
Ruxolitinib (INCB018424)
Price: 200mg, $450;500mg, $850; 1g $1250; 2g, $1850
WHI-P154
WHI-P154
Price: 200mg, $659;500mg, $1150; 1g, $1595; 2g, $2355