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Product name : TG 101348
Item : cc67
Price : 10mg, $120; 50mg,$455; 100mg, $745; 200mg,$1295
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
TG101348 (SAR302503) is an orally available inhibitor of Janus kinase 2 (JAK-2) developed for the treatment of patients with myeloproliferative diseases including myelofibrosis. TG-101348 acts as a competitive inhibitor of protein kinase JAK-2 with IC50=6 nM; related kinases FLT3 and RET are also sensitive, with IC50=25 nM and IC50=17 nM, respectively. Significantly less activity was observed against other tyrosine kinases including JAK3 (IC50=169 nM). In treated cells the inhibitor blocks downstream cellular signalling (JAK-STAT) leading to suppression of proliferation and induction of apoptosis.[1][2]
 
Reference:
[1] Leukemia 2008, 22, 1790-1792.
[2] Cancer Cell 2008, 14, 311-320.
 
 
Chemical Information
Molecular Weight (WM):
524.68
Formula:
C27H36N6O3S
CAS No:
936091-26-8
Purity:
≥ 98%
Synonyms:
TG 101348, SAR-302503, SAR 302503
 
DMSO ≥ 105 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 42 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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