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Product name : PF 3845
Item : cc145
Price : 10mg, $95, 50mg, $395; 100mg, $695; 200mg, $995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
PF-3845 is a potent, selective, and irreversible inhibitor of Fatty Acid Amide Hdryolase (FAAH) with Ki of 0.23 μM. FAAH degrades N-acyl ethanolamines (NAEs), including the endocannabinoid arachidonoyl ethanolamide (AEA). It covalently binds FAAH on Ser241 at the catalytic site, resulting in prolonged elevation of AEA in the brain and plasma in rats after treatment. PF3845 significantly and persistently reduces inflammatory pain in rats through a cannabinoid receptor-dependent mechanism.  [1][2
 
Reference:
[1] Chem. Biol. 2009, 16, 411-420.
[2] Expert Opin. Drug Discov. 2009, 4, 763-784.
 
 
Chemical Information
Molecular Weight (WM):
456.46
Formula:
C24H23F3N4O2
CAS No:
1196109-52-0
Purity:
≥ 98%
Synonyms:
PF 3845
 
DMSO ≥ 91 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 91 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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