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Product name : OSI 930
Item : cc339
Price : 10mg, $225; 50mg, $595; 100mg, $995; 200mg, $1695
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
OSI-930 is a potent thiophene receptor tyrosine kinase inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively. Tyrosine kinase inhibitor OSI930 inhibits stem cell factor receptor (c-Kit) and the vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of both tumor cell proliferation and tumor angiogenesis. Both c-Kit and VEGFR2 are overexpressed in a variety of cancers. [1][2]
 
Reference:
[1] Cancer Res. 2006, 66,1015-1024.
[2] Mol. Cancer Ther. 2005, 4, 1186-1197.
 
 
Chemical Information
Molecular Weight (WM):
443.44
Formula:
C22H16F3N3O2F
CAS No:
728033-96-3
Purity:
≥ 98%
Synonyms:
OSI 930
 
DMSO ≥ 89 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 6 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 
 

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