Favorite  |  Set Home
Products > Receptor Tyrosine Kinase > VEGFR > Regorafenib (BAY 73-4506)
Product name : Regorafenib (BAY 73-4506)
Item : cc195
Price : 10mg, $195; 50mg, $595; 100mg, $995; 200mg, $1455
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature. VEGFRs are receptor tyrosine kinases that play important roles in tumor angiogenesis. Inhibition of the receptor tyrosine kinases RET, KIT, and PDGFR, and the serine/threonine-specific Raf kinase are involved in tumor cell signaling. vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR and Raf kinases, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation.  [1][2]
 
Reference:
[1] Int. J Cancer 2011, 129, 245-255.
[2] Clin. Cancer Res. 2012, 18, 2658-2667.
 
 
Chemical Information
Molecular Weight (WM):
482.82
Formula:
C21H15ClF4N4O3
CAS No:
755037-03-7
Purity:
≥ 98%
Synonyms:
BAY 73-4506
 
DMSO ≥ 97 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 8 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

Related Products :
KRN 633
KRN 633
Price: 10mg, $245; 50mg, $725; 100mg, $1295; 200mg, $1895
SU 5402
SU 5402
Price: 10mg, $275; 50mg, $795; 100mg, $1295; 200mg, $2295
Brivanib alaninate (BMS-582664)
Brivanib alaninate (BMS-582664)
Price: 10mg, $375; 50mg, $825; 100mg, $1195;200mg, $1995
Brivanib (BMS 540215)
Brivanib (BMS 540215)
Price: 10mg, $275; 50mg, $795; 100mg, $1295; 200mg, $1995
Vatalanib (CGP-79787, ZK-222584)
Vatalanib (CGP-79787, ZK-222584)
Price: 10mg, $55; 50mg, $175; 100mg, $345; 200mg, $545
R1530
R1530
Price: 100mg, $845; 200mg, $1285
RAF 265 (CHIR 265)
RAF 265 (CHIR 265)
Price: 10mg, $275; 50mg, $875; 100mg, $1295; 200mg, $2295
Motesanib Diphosphate (AMG-706)
Motesanib Diphosphate (AMG-706)
Price: 10mg, $265; 50mg, $795; 100mg, $1395; 200mg, $2295