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Product name : Regorafenib (BAY 73-4506)
Item : cc195
Price : 5g, $650;10g, $1050; 20g $1650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 755037-03-7
Molecular Weight : 482.82
Formula : C₂₁H₁₅ClF₄N₄O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. Regorafenib (BAY 73-4506) is an orally bioavailable multikinase inhibitor targeting both the tumor and its vasculature. VEGFRs are receptor tyrosine kinases that play important roles in tumor angiogenesis. Inhibition of the receptor tyrosine kinases RET, KIT, and PDGFR, and the serine/threonine-specific Raf kinase are involved in tumor cell signaling. vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR and Raf kinases, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation.  [1][2]
 
Reference:
[1] Int. J Cancer 2011, 129, 245-255.
[2] Clin. Cancer Res. 2012, 18, 2658-2667.
 
 
Chemical Information
Molecular Weight (WM):
482.82
Formula:
C21H15ClF4N4O3
CAS No:
755037-03-7
Purity:
≥ 98%
Synonyms:
BAY 73-4506
 
DMSO ≥ 97 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 8 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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