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Product name : PD 173074
Item : cc523
Price : 10mg, $95, 50mg, $395; 100mg, $675; 200mg, $995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
PD 173074 is a potent and selective inhibitor of FGFR tyrosine kinase activity, blocking autophosphorylation of FGFR1 with an IC50 value of 21.5 nM.The fibroblast growth factor receptors (FGFRs) are cell surface receptors with intrinsic tyrosine kinase activity, which is necessary for receptor activation and signal propagation. PD-173074 weakly inhibits PDGFR and c-Src (IC50 = 17.6 and 19.8 μM, respectively) and has no effect on EGFR, InsR, MEK, or PKC.PD173074 also prevents signaling, at nanomolar levels, through FGFR2-5. Inhibition of FGFR signaling using PD 173074, impairs angiogenesis as well as self-renewal of stem cells via ERK1/2 activation.  [1][2]
 
Reference:
[1] J Pharmacol. Exp. Ther. 2010, 332, 795-802.
[2] Clin. Cancer Res. 2012, 18, 2658-2667.
 
 
Chemical Information
Molecular Weight (WM):
523.67
Formula:
C28H41N7O3
CAS No:
219580-11-7
Purity:
≥ 98%
Synonyms:
PDF-173074
 
DMSO ≥ 105 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 105 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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