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Product name : RAF 265 (CHIR 265)
Item : cc117
Price : 10mg, $275; 50mg, $875; 100mg, $1295; 200mg, $2295
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
RAF265 (CHIR-265) is an orally-bioavailable, selective, potent inhibitor of B-Raf and VEGFR-2 with IC50 of 3-60 nM and EC50 of 30 nM, respectively. B-Raf/VEGFR-2 inhibitor RAF-265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR-2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are frequently upregulated in neoplasms. [1][2]

Reference:
[1] Mol. Cancer Ther. 2010, 9, 358-368.
[2] Cancer Res. 2011, 71, 4280-4291.
 
 
Chemical Information
Molecular Weight (WM):
518.41
Formula:
C24H16F6N6O
CAS No:
927880-90-8
Purity:
≥ 98%
Synonyms:
CHIR265, CHIR 265, Raf 265
 
DMSO ≥ 104 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 33 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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