Apoptosis
Btk
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Product name : RAF 265 (CHIR 265)
Item : cc117
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 927880-90-8
Molecular Weight : 518.41
Formula : C₂₄H₁₆F₆N₆O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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RAF265 (CHIR-265) is an orally-bioavailable, selective, potent inhibitor of B-Raf and VEGFR-2 with IC50 of 3-60 nM and EC50 of 30 nM, respectively. B-Raf/VEGFR-2 inhibitor RAF-265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR-2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are frequently upregulated in neoplasms. [1][2]
Reference: [1] Mol. Cancer Ther. 2010, 9, 358-368.
[2] Cancer Res. 2011, 71, 4280-4291.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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