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Products > Receptor Tyrosine Kinase > VEGFR > Motesanib Diphosphate (AMG-706)
Product name : Motesanib Diphosphate (AMG-706)
Item : cc524
Price : 10mg, $265; 50mg, $795; 100mg, $1395; 200mg, $2295
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM, 3 nM, 6 nM, 84 nM, 8 nM and 59 nM, respectively. Motesanib diphosphate  is the orally bioavailable diphosphate salt of a multiple-receptor tyrosine kinase inhibitor with potential antineoplastic activity. Motesanib selectively targets and inhibits vascular endothelial growth factor (VEGFR), platelet-derived growth factor (PDGFR), kit, and Ret receptors, thereby inhibiting angiogenesis and cellular proliferation.   [1][2]
 
Reference:
[1] J Clin. Oncol. 2007, 25, 2369-2376.
[2] Cancer Res. 2006, 66, 8715-8721.
 
 
Chemical Information
Molecular Weight (WM):
569.44
Formula:
C22H23N5O·2H3PO4
CAS No:
857876-30-3
Purity:
≥ 98%
Synonyms:
AMG706
 
DMSO ≥ 114 mg/mL
Solubility (25℃)
Water ≥ 114 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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