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Product name : E7080 (Lenvatinib)
Item : cc445
Price : 10mg, $195; 50mg, $595; 100mg, $995; 200mg, $1455
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
E7080 (Lenvatinib) is the most potent dual inhibitor of VEGF-R3 tyrosine kinase (IC50=5.2 nM) as well as VEGF-R2 tyrosine kinase (IC50=4.0 nM) among those small-molecule inhibitors of VEGF-R kinases, such as sunitinib, sorafenib, and CEP-7055. E-7080 blocks VEGFR2 activation by VEGF, resulting in inhibition of the VEGF receptor signal transduction pathway, decreased vascular endothelial cell migration and proliferation, and vascular endothelial cell apoptosis. [1][2]
 
Reference:
[1] Clin. Cancer Res. 2009, 15, 7229-7237.
[2] Int. J Cancer 2008, 122, 664-671.
 
 
Chemical Information
Molecular Weight (WM):
426.85
Formula:
C21H19ClN4O4
CAS No:
417716-92-8
Purity:
≥ 98%
Synonyms:
E 7080
 
DMSO ≥ 16 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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