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Products > Receptor Tyrosine Kinase > VEGFR > Cabozantinib (XL-184)
Product name : Cabozantinib (XL-184)
Item : cc10
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 849217-68-1
Molecular Weight : 501.51
Formula : C₂₈H₂₄FN₃O₅
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
XL184 (Cabozantinib) is a potent broad-spectrum tyrosine kinase inhibitor of VEGFR2 and c-Met with IC50 of 0.035 nM and 1.3 nM, respectively.XL-184 strongly binds to and inhibits several tyrosine receptor kinases. Specifically, XL 184 appears to have a strong affinity for the hepatocyte growth factor receptor (Met) and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in inhibition of tumor growth and angiogenesis, and tumor regression. This agent has also been shown to inhibit mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (Flt3) and tyrosine-protein kinase receptor (Tie-2). [1][2]
 
Reference:
[1] Expert Opin. Investig. Drugs 2011, 20, 407-413.
[2] Mol. Cancer Ther. 2011, 10, 2298-3308.
 
 
Chemical Information
Molecular Weight (WM):
501.51
Formula:
C28H24FN3O5
CAS No:
849217-68-1
Purity:
≥ 98%
Synonyms:
BMS-907351, BMS907351, BMS 907351
 
DMSO ≥ 117 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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