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Product name : KRN 633
Item : cc528
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 286370-15-8
Molecular Weight : 416.86
Formula : C₂₀H₂₁ClN₄O₄
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
KRN 633 is an ATP-competitive inhibitor of VEGFR kinase, with IC50 values of 170 nM, 160 nM and 125 nM for VEGFR-1, VEGFR-2 and VEGFR-3, respectively. Vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 play a central role in angiogenesis, which is necessary for solid tumors to expand and metastasize. Specific inhibitors of VEGFR-2 tyrosine kinase are therefore thought to be useful for treating cancer. [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2006, 5, 80-88.
[2] J Pharmacol. Sci. 2010, 112, 290-298.
 
 
Chemical Information
Molecular Weight (WM):
416,86
Formula:
C20H21ClN4O4
CAS No:
286370-15-8
Purity:
≥ 98%
Synonyms:
KRN-633, KRN633
 
DMSO ≥ 9 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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