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Products > Receptor Tyrosine Kinase > VEGFR > Vatalanib (CGP-79787, ZK-222584)
Product name : Vatalanib (CGP-79787, ZK-222584)
Item : cc530
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS :  212141-54-3
Molecular Weight : 346.81
Formula : C₂₀H₁₅ClN₄
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
Vatalanib (PTK787) is an inhibitor to VEGF receptor/KDR, VEGF receptor/Flt-1, VEGF receptor/Flk, c-Kit and PDGFR-βVEGFR with IC50 of 0.037 μM, 0.077 μM, 0.27 μM, 0.73 μM and 0.58 μM, respectively. PTK-787 binds to and inhibits the protein kinase domain of vascular endothelial growth factor receptors 1 and 2; both receptor tyrosine kinases are involved in angiogenesis. This agent also binds to and inhibits related receptor tyrosine kinases, including platelet-derived growth factor (PDGF) receptor, c-Kit, and c-Fms.   [1][2]
 
Reference:
[1] Cancer Res. 2000, 60, 4819-4824.
[2] Br. J Cancer 2001, 85, 2010-2016.
 
 
Chemical Information
Molecular Weight (WM):
419.74
Formula:
C20H15ClN4·2HCl
CAS No:
212141-54-3, 212141-51-0 (HCl)
Purity:
≥ 98%
Synonyms:
ZK-222584, ZK222584, PTK 787
 
DMSO ≥ 28 mg/mL
Solubility (25℃)
Water ≥ 10 mg/mL
 
Ethanol ≥ 6 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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