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Product name : BMS 754807
Item : cc531
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1001350-96-4
Molecular Weight : 461.49
Formula : C₂₃H₂₄FN₉O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
BMS-754807 inhibits the phosphorylation of IGF-1R (IC50 = 13nM) and the downstream targets Akt (IC50 = 22nM) and MAPK (IC50 = 13nM) in the IGF-Sal cell line with IC50 consistent with the antiproliferative IC50 (7 nM) in this cell line. BMS754807 binds reversibly to and inhibits the activities of IGF-1R and InsR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-1R and InsR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in mitogenesis, angiogenesis, and tumor cell survival.  [1][2]
 
Reference:
[1] Cancer Res. 2010, 70, 7221-7231.
[2] Mol. Cancer Ther. 2009, 8, 3341-3349.
 
 
Chemical Information
Molecular Weight (WM):
461.49
Formula:
C23H24FN9O
CAS No:
1001350-96-4
Purity:
≥ 98%
Synonyms:
BMS 754807
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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