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Products > Receptor Tyrosine Kinase > IGF-1R > NVP-ADW742 (ADW 742)
Product name : NVP-ADW742 (ADW 742)
Item : cc532
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 475488-23-4
Molecular Weight : 453.58
Formula : C₂₈H₃₁N₅O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM. NVP-ADW742 exhibits a 6-fold greater selectivity for IGF-1R versus InsR with IC50 of 2.8 μM; minimal inhibitory activity against c-Kit, HER1, PDGFR, VEGFR-2, or Bcr-Abl p210 with IC50 greater than 5 μM.  NVP-ADW742 could induce apoptosis in both HL-60 cell line and primary AML blasts. NVP-ADW742 also induced Akt dephosphorylation, which might subsequently induce p38 phosphorylation and decrease antiapoptotic protein Bcl-2 expression in HL-60 cells.  [1][2]
 
Reference:
[1] Clin. Cancer Res. 2005, 11, 1563-1571.
[2] Biochem. Pharmacol. 2005, 70, 1685-1696.
 
 
Chemical Information
Molecular Weight (WM):
453.58
Formula:
C28H31N5O
CAS No:
475488-23-4
Purity:
≥ 98%
Synonyms:
ADW742, ADW-742, GSK552602A
 
DMSO ≥ 14 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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