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Product name : Quizartinib (AC220)
Item : cc62
Price : 10mg, $320; 50mg, $795; 100mg, $1295; 200mg,$2175
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
AC220 (Quizartinib) is a potent and selective inhibitor of FLT3 with IC50 values of 1.1 nM and 4.2 nM for FLT3-ITD and FLT3-WT autophosphorylation, respectively.AC-220 selectively inhibits class III receptor tyrosine kinases, including FMS-related tyrosine kinase 3 (FLT3/STK1), colony-stimulating factor 1 receptor (CSF1R/FMS), stem cell factor receptor (SCFR/KIT), and platelet derived growth factor receptors (PDGFRs), resulting in inhibition of ligand-independent leukemic cell proliferation and apoptosis. Mutations in FLT3, resulting in constitutive activation, are the most frequent genetic alterations in acute myeloid leukemia (AML) and occur in approximately one-third of AML cases.  [1][2]
 
Reference:
[1] Blood 2009, 114, 2984-2992.
[2] J Med. Chem. 2009, 52, 7808-7816.
 

Chemical Information
Molecular Weight (WM):
560.67
Formula:
C29H32N6O4S
CAS No:
950769-58-1,1132827-21-4 (2HCl), 1132827-24-7 (methanesulfonate)
Purity:
≥ 98%
Synonyms:
AC 220
 
DMSO ≥ 112 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 4 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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