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Products > Receptor Tyrosine Kinase > Flt > KW 2449
Product name : KW 2449
Item : cc533
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1000669-72-6
Molecular Weight : 332.4
Formula : C₂₀H₂₀N₄O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
KW-2449 inhibits FLT3 and ABL kinases with IC50 of 6.6 nM and 14 nM, respectively.KW2449 showed the potent growth inhibitory effects on leukemia cells with FLT3 mutations by inhibition of the FLT3 kinase, resulting in the down-regulation of phosphorylated-FLT3/STAT5, G1 arrest, and apoptosis.  [1][2]
 
Reference:
[1] Blood 2009, 113, 3938-3946.
[2] Blood 2009, 114, 1607-1617.
 
 
Chemical Information
Molecular Weight (WM):
332.40
Formula:
C20H20N4O
CAS No:
1000669-72-6
Purity:
≥ 98%
Synonyms:
KW 2449
 
DMSO ≥ 67 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 67 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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