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Product name : Tandutinib (MLN518)
Item : cc355
Price : 100mg, $125; 200mg, $220; 1g, $825
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Tandutinib (MLN518, CT53518) is an ATP-competitive and highly selective inhibitor of FLT3, PDGFR and c-Kit with IC50 of 0.22 μM, 0.20 μM and 0.17 μM, respectively. Tandutinib treatment leads to significant apoptosis by 51% and 78% at 24 and 96 hours, respectively, due to specific FLT3 inhibition. Tandutinib preferentially inhibits the growth of blast colonies from FLT3 ITD-positive compared with ITD-negative patients with AML, without affecting colony formation by normal human progenitor cells.  [1][2]
 
Reference:
[1] Blood 2006, 108, 3674-3681.
[2] IDrugs 2008, 11, 46-56.
 

Chemical Information
Molecular Weight (WM):
562.70
Formula:
C31H42N6O4
CAS No:
387867-13-2
Purity:
≥ 98%
Synonyms:
CT-53518, CT 53518, MLN-518, MLN 518
 
DMSO ≥ 11 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 19 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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