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Product name : Canertinib
Item : cc178
Price : 10mg, $55; 50mg, $195; 100mg, $345; 200mg, $575
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Canertinib (CI-1033, PD-183805) is a potent tyrosine kinase inhibitor of EGFR and erbB2 with IC50 of 1.5 nM and 9.0 nM, respectively.Canertinib binds to the intracellular domains of epidermal growth factor receptor tyrosine kinases (ErbB family), irreversibly inhibiting their signal transduction functions and resulting in tumor cell apoptosis and suppression of tumor cell proliferation. This agent also acts as a radiosensitizing agent and displays synergistic activity with other chemotherapeutic agents.  [1][2]
 
Reference:
[1] J Med. Chem. 2000, 43, 1380-1397.
[2] J Biol. Chem. 2001, 276, 14842-14827.
 
 
Chemical Information
Molecular Weight (WM):
485.94
Formula:
C24H25ClFN5O3
CAS No:
267243-28-7, 289499-45-2 (2HCl)
Purity:
≥ 98%
Synonyms:
PD183805, CI1033, CI 1033, PD 183805
 
DMSO ≥ 6 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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