Apoptosis
Btk
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Product name : Canertinib
Item : cc178
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 267243-28-7
Molecular Weight : 485.94
Formula : C₂₄H₂₅ClFN₅O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Canertinib (CI-1033, PD-183805) is a potent tyrosine kinase inhibitor of EGFR and erbB2 with IC50 of 1.5 nM and 9.0 nM, respectively.Canertinib binds to the intracellular domains of epidermal growth factor receptor tyrosine kinases (ErbB family), irreversibly inhibiting their signal transduction functions and resulting in tumor cell apoptosis and suppression of tumor cell proliferation. This agent also acts as a radiosensitizing agent and displays synergistic activity with other chemotherapeutic agents. [1][2]
Reference:
[1] J Med. Chem. 2000, 43, 1380-1397.
[2] J Biol. Chem. 2001, 276, 14842-14827.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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